Product Description: Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2].
Applications: Cancer-programmed cell death
Formula: C20H13BrN2O3S2
References: [1]Kumar GA, et, al. Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis. Sci Rep. 2019 Sep 2; 9(1): 12636./[2]Smith CM, et, al. Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells. Mol Cancer. 2013 Jan 17; 12:4.
CAS Number: 1419320-73-2
Molecular Weight: 473.36
Compound Purity: 98.38
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Apoptosis