PLK1-IN-10, CAS 2991469-21-5

Product Description: PLK1-IN-10 (Compound 4Bb) is an orally active PLK1 PBD (polo-box domain) inhibitor. PLK1-IN-10 blocks the interaction of PLK1 with the cell division regulator protein 1 (PRC1) and decreases the protein expression of the CDK1-Cyclin B1 complex. PLK1-IN-10 reacts with glutathione (GSH) to increase cellular oxidative stress, ultimately leading to cell death[1].

Applications: Cancer-Kinase/protease

Formula: C23H22FN3O4S

References: [1]Li P, Li Y, et al. Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells. Eur J Med Chem. 2024 May 5;271:116416.

CAS Number: 2991469-21-5

Molecular Weight: 455.50

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Polo-like Kinase (PLK)

• Artikelnummer: MEXHY-161521-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161521-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK