Prexasertib (lactate), CAS 2781996-46-9

Product Description: Prexasertib lactate (LY2606368 lactate) is the lactate form of Prexasertib (HY-18174). Prexasertib lactate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib lactate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib lactate shows potent anti-tumor activity[1][2].

Applications: Cancer-Kinase/protease

Formula: C21H25N7O5

References: [1]King C, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015 Sep;14(9):2004-1/[2]Yin Y, et al. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017 Mar 1;7(3):473-483.

CAS Number: 2781996-46-9

Molecular Weight: 455.47

Research Area: Cancer

Target: Apoptosis;Checkpoint Kinase (Chk);DNA/RNA Synthesis

• Artikelnummer: MEXHY-18174H-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18174H-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK