Propargyl-PEG1-acid, CAS 55683-37-9

Product Description: Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1]. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C6H8O3

References: [1]Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

CAS Number: 55683-37-9

Molecular Weight: 128.13

Compound Purity: 97.0

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: PROTAC Linkers

• Artikelnummer: MEXHY-130504-1G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130504-1G
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK