Propargyl-PEG4-acid, CAS 1415800-32-6

Product Description: Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Applications: Cancer-programmed cell death

Formula: C12H20O6

References: [1]Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

CAS Number: 1415800-32-6

Molecular Weight: 260.28

Compound Purity: 97.0

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: PROTAC Linkers

• Artikelnummer: MEXHY-130481-500
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-130481-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK