PROTAC ATR degrader-2, CAS 3010273-12-5

Product Description: PROTAC ATR degrader-2 (Compound 8i) is a PROTAC degrader for ATR, through of . PROTAC ATR degrader-2 degrades ATR in acute myeloid leukemia (AML) cells MV-4-11 and MOLM-13, with DC50 of 22.9 and 34.5 nM. APROTAC ATR degrader-2 induces apoptosis, inhibits proliferations of AML cells. PROTAC ATR degrader-2 exhibits good pharmacokinetics charachers and antitumor efficacy against AML in mouse model. (Pink: ATR ligand (HY-161616); Blue:E3 ligase ligand Lenalidomide (HY-A0003); Black: linker)[1]

Applications: Cancer-programmed cell death

Formula: C40H41N9O6

References: [1]Wang Y, et al., Discovery of Selective and Potent ATR Degrader for Exploration its Kinase-Independent Functions in Acute Myeloid Leukemia Cells. Angew Chem Int Ed Engl. 2024 Apr 22;63(17):e202318568.

CAS Number: 3010273-12-5

Molecular Weight: 743.81

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;PROTACs

• Artikelnummer: MEXHY-161615-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161615-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK