PROTAC PARP1 degrader-1

Product Description: PROTAC PARP1 degrader-1 (Compound CN0) is a PROTAC degrader of PARP1. PROTAC PARP1 degrader-1 activates the cGAS/STING immunity pathway and eventually enhances T cell killing of tumor cells. PROTAC PARP1 degrader-1 inhibits DNA damage repair, resulting in highly efficient accumulation of cytosolic DNA fragments (Blue: CRBN ligand, Black: linker; Pink: PARP1 inhibitor)[1].

Formula: C32H28N6O5

References: [1]Lin S, et al. Discovery of CN0 as a novel proteolysis-targeting chimera (PROTAC) degrader of PARP1 that can activate the cGAS/STING immunity pathway combined with daunorubicin. Bioorg Med Chem. 2022 Sep 15;70:116912.

Molecular Weight: 576.60

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: PARP;PROTACs

• Artikelnummer: MEXHY-158045-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158045-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK