PROTAC TEAD degrader-1

Product Description: PROTAC TEAD degrader-1 (Compound 27) is a PROTAC degrader for transcriptional enhanced associate domain (TEAD). PROTAC TEAD degrader-1 selectively degrades the Flag TEAD2 in a ubiquitin proteasome-dependent manner, with a DC50 of 54.1 nM in 293T cells, inhibits proliferation of NF2-deficient NCI-H226 with an IC50 of 0.21 μM, and regulates expressions of yes associated protein (YAP) target genes. (Pink: TEAD ligand (HY-158400); Black: linker (HY-W008474); Blue: E3 ligase ligand (HY-W087383))[1]

Applications: Cancer-programmed cell death

Formula: C44H41F3N6O7

References: [1]Li H, et al., Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS Med Chem Lett. 2024 Apr 22;15(5):631-639. 

Molecular Weight: 822.83

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: PROTACs;YAP

• Artikelnummer: MEXHY-158342-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158342-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK