Pyridostatin (TFA), CAS 1472611-44-1

Product Description: Pyridostatin (RR82) TFA is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin TFA promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin TFA targets the proto-oncogene Src. Pyridostatin TFA reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2][3].

Applications: Cancer-programmed cell death

Formula: C33H33F3N8O7

References: [1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5./[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28./[3]Moruno-Manchon JF, et al. The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons. Aging (Albany NY). 2017;9(9):1957-1970.

CAS Number: 1472611-44-1

Molecular Weight: 710.66

Compound Purity: 99.54

Research Area: Cancer

Solubility: H2O : 100 mg/mL (ultrasonic)

Target: G-quadruplex

• Artikelnummer: MEXHY-15176B-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15176B-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK