(R)-Roscovitine, CAS 186692-46-6

Product Description: (R)-Roscovitine (Seliciclib) is an orally bioavailable and selective CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively.

Applications: Cancer-Kinase/protease

Formula: C19H26N6O

References: [1]Gary C, et al. Selective antitumor activity of roscovitine in head and neck cancer. Oncotarget. 2016 May 23./[2]Bai X, et al. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via erk1/2/pparγ pathway. Oncotarget. 2016 Apr 27./[3]Meijer L, et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem. 1997 Jan 15;243(1-2):527-36.

CAS Number: 186692-46-6

Molecular Weight: 354.45

Compound Purity: 99.84

Research Area: Cancer

Solubility: DMSO : ≥ 100 mg/mL

Target: CDK

• Artikelnummer: MEXHY-30237-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-30237-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK