RA-XII, CAS 143343-98-0

Product Description: RA-XII is bicyclic hexapeptidic glucoside , which exhibits antitumor and anti-inflammatory activity. RA-XII activates Akt-mTOR singaling pathway, inhibits the formation of autophagosomes, and thus suppresses autophagy. RA-XII induces apoptosis through AMPK/mTOR/P70S6K pathway. RA-XII inhibit metastasis via reducing cell adhesion and invasion in breast cancer cells. RA-XII attenuates anti-inflammatory efficacy against acute kidney injury through HO-1/Nrf2 pathway[1][2][3][4].

Formula: C46H58N6O14

References: [1]Wang J, et al., RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells. J Ethnopharmacol. 2021 Feb 10;266:113438./[2]Leung HW, et al., RA-XII inhibits tumour growth and metastasis in breast tumour-bearing mice via reducing cell adhesion and invasion and promoting matrix degradation. Sci Rep. 2015 Nov 23;5:16985. /[3]An X, et al., RA-XII exerts anti-oxidant and anti-inflammatory activities on lipopolysaccharide-induced acute renal injury by suppressing NF-κB and MAPKs regulated by HO-1/Nrf2 pathway. Biochem Biophys Res Commun. 2018 Jan 15;495(3):2317-2323. /[4]Song L, et al., Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells. Molecules. 2017 Nov 11;22(11):1934.

CAS Number: 143343-98-0

Molecular Weight: 918.98

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Akt;Apoptosis;Autophagy;mTOR

• Artikelnummer: MEXHY-P10298-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P10298-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK