RG7112D, CAS 2360561-90-4

Product Description: RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels[1].

Formula: C36H42Cl2N4O4

References: [1]Clare M Adams, et al. Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer. Cancer Discov. 2023 May 4;13(5):1210-1229.

CAS Number: 2360561-90-4

Molecular Weight: 665.65

Research Area: Cancer

Target: MDM-2/p53

• Artikelnummer: MEXHY-158685-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158685-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK