Ropivacaine (hydrochloride monohydrate) (Standard), CAS 132112-35-7

Product Description: Ropivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Ropivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese[1][2]. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane[3]. Ropivacaine is widely used for regional anesthesia and neuropathic pain management in vivo[1].

Formula: N/A

References: [1]Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321./[2]Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28./[3]Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717./[4]Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6.

CAS Number: 132112-35-7

Molecular Weight: N/A

Research Area: Neurological Disease; Cardiovascular Disease; Cancer

Target: Potassium Channel;Sodium Channel

• Artikelnummer: MEXHY-B0563AR-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0563AR-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK