RTx-161

Product Description: RTx-161 is an allosteric Polθ polymerase inhibitor with an IC50 value of 4.1 nM. RTx-161 selectively kills HR-deficient cancer cells and suppresses PARP inhibitor (PARPi) resistance in multiple genetic backgrounds, including HR-proficient cells. Additionally, RTx-161 can induce apoptosis[1].

Formula: C21H18F7N3O4

References: [1]Fried W, et al. Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors[J]. Nature communications, 2024, 15(1): 2862.

Molecular Weight: 509.37

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;DNA/RNA Synthesis

• Artikelnummer: MEXHY-161430-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161430-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK