Sacubitril (sodium), CAS 149690-05-1

Product Description: Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19[1][2][3].

Applications: COVID-19-anti-virus

Formula: C24H28NNaO5

References: [1]Hegde, L.G., et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacol 11, P33 (2011). /[2]Vitiello A, et al. Sacubitril, valsartan and SARS-CoV-2. BMJ Evid Based Med. 2020 Jul 27:bmjebm-2020-111497. /[3]Chrysant SG. Pharmacokinetic, pharmacodynamic, and antihypertensive effects of the neprilysin inhibitor LCZ-696: sacubitril/valsartan. J Am Soc Hypertens. 2017 Jul;11(7):461-468.

CAS Number: 149690-05-1

Molecular Weight: 433.47

Compound Purity: 99.95

Research Area: Infection; Cardiovascular Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Neprilysin

• Artikelnummer: MEXHY-15407B-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15407B-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK