Description: SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
CAS Number: 912545-86-9
Formula: C28H28ClN3OS
Molecular Weight: 490,06
References: Xu H, et al. Directed Differentiation of V3 Interneurons from Mouse Embryonic Stem Cells. Stem Cells Dev. 2015 Nov 15;24(22):2723-32.