Scalaradial, CAS 53527-28-9

Product Description: Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC50 of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C27H40O4

References: [1]Starkus JG, et al., Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels. J Nat Prod. 2017 Oct 27;80(10):2741-2750./[2]de Carvalho MS, et al., Two-step inactivation of bee venom phospholipase A2 by scalaradial. Biochem Pharmacol. 1991 Sep 27;42(8):1621-6. /[3]Xie Y, et al., Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A(2) inhibitor. Cancer Biol Ther. 2006 Aug;5(8):988-92.

CAS Number: 53527-28-9

Molecular Weight: 428.60

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Akt;ERK;Phospholipase;TRP Channel

• Artikelnummer: MEXHY-123245-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-123245-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK