SE-7552, CAS 2243575-79-1

Product Description: SE-7552, a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM. SE-7552 is greater than 850-fold selectivity versus all other known HDAC isozymes. SE-7552 is capable of blocking multiple myeloma growth in vivo. SE-7552 acts as an anti-obesity agent in diet-induced obese mice[1][2].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C15H12F3N5O

References: [1]Jason A Holt, et al. SE-7552, a Highly Selective, Non-Hydroxamate Inhibitor of Histone Deacetylase-6 Blocks Multiple Myeloma Growth In Vivo. Blood (2018) 132 (Supplement 1): 3215./[2]Beate König, et al. 2-(Difluoromethyl)-1,3,4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation? ACS Pharmacol. Transl. Sci. 2024, February 20.

CAS Number: 2243575-79-1

Molecular Weight: 335.28

Compound Purity: 99.48

Research Area: Cancer; Metabolic Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: HDAC

• Artikelnummer: MEXHY-161305-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161305-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK