Serpinin, CAS 1383743-23-4

Product Description: Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function[1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects[2].

Formula: C125H204N32O46

References: [1]Koshimizu H, et al. Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells. Mol Endocrinol. 2011 May;25(5):732-44. /[2]Loh YP, et al. Chromogranin A and derived peptides in health and disease. J Mol Neurosci. 2012 Oct;48(2):347-56.

CAS Number: 1383743-23-4

Molecular Weight: 2891.14

Research Area: Endocrinology; Neurological Disease

Solubility: 10 mM in DMSO

Target: Others

• Artikelnummer: MEXHY-P10336-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P10336-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK