SIK-IN-3

Product Description: SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 3 nM in human macrophages[1].

Applications: COVID-19-immunoregulation

Formula: C24H25N5OS

References: [1]Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1.

Molecular Weight: 431.55

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: AMPK

• Artikelnummer: MEXHY-161442-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161442-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK