Sitagliptin (phosphate) (Standard), CAS 654671-78-0

Product Description: Sitagliptin (phosphate) (Standard) is the analytical standard of Sitagliptin (phosphate). This product is intended for research and analytical applications. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1].

Formula: N/A

References: [1]Thomas, L., et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylm ethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of acti/[2]Kim, S.J., et al., Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes, 2009. 58(3): p. 641-51./[3]Sangle, G.V., et al., Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue. Endocrinology, 2012. 153(2): p. 564-73./[4]Kim, S.J., et al., Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice. Diabetes, 2008. 57(5): p. 1331-9./[5]Beconi, M.G., et al. Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs. Drug Metab Dispos, 2007. 35(4): p. 525-32.

CAS Number: 654671-78-0

Molecular Weight: N/A

Research Area: Metabolic Disease

Target: Autophagy;Dipeptidyl Peptidase

• Artikelnummer: MEXHY-13749AR-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13749AR-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK