Product Description: Smad2/3-IN-2 (Compound 3) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively[1].
Formula: C18H21ClO5
References: [1]Seipp K, et al., Total Synthesis, Structure Reassignment, and Biological Evaluation of the Anti-Inflammatory Macrolactone 13-Hydroxy-14-deoxyoxacyclododecindione. J Nat Prod. 2024 Mar 31.
Molecular Weight: 352.81
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: STAT;TGF-beta/Smad