Description: Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase.
CAS Number: 104987-11-3
Formula: C44H69NO12
Molecular Weight: 804,02
References: Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF‑1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92.