Tauro-β-muricholic acid (sodium), CAS 145022-92-0

Product Description: Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].

Applications: Cancer-programmed cell death

Formula: C26H44NNaO7S

References: [1]Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35./[2]Wahlström A, et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017 Feb;58(2):412-419./[3]Fu T, et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell. 2019 Feb 21;176(5):1098-1112.e18.

CAS Number: 145022-92-0

Molecular Weight: 537.68

Compound Purity: 98.60

Research Area: Cancer

Solubility: DMSO : 10 mg/mL (ultrasonic;warming)

Target: FXR

• Artikelnummer: MEXHY-135103-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-135103-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK