Product Description: TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC50 of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD[1].
Applications: Cancer-programmed cell death
Formula: C23H23F3N3O3P
References: [1]Dong Liu. Small molecule compound having phosphorylated aryl structure, and use thereof. WO2024061366A1.