Description: Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.
CAS Number: 85622-93-1
Formula: C6H6N6O2
Molecular Weight: 194,15
References: Mhaidat NM, et al. Temozolomide induces senescence but not apoptosis in human melanoma cells. Br J Cancer. 2007 Nov 5;97(9):1225-33.