TH6342

Product Description: TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe[1].

Formula: C19H16ClN5

References: [1]Zhang SM, et al. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel. iScience. 2024 Jan 13;27(2):108907.

Molecular Weight: 349.82

Compound Purity: 98.90

Research Area: Infection

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Bacterial;HIV

• Artikelnummer: MEXHY-161296-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161296-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK