Thalidomide-5-propargyl, CAS 2226303-74-6

Product Description: Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].

Formula: C16H12N2O5

References: [1]Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.

CAS Number: 2226303-74-6

Molecular Weight: 312.28

Compound Purity: 95.87

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;E3 Ligase Ligand-Linker Conjugates

• Artikelnummer: MEXHY-W457950-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W457950-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK