Tilorone (dihydrochloride) (Standard), CAS 27591-69-1

Product Description: Tilorone (dihydrochloride) (Standard) is the analytical standard of Tilorone (dihydrochloride). This product is intended for research and analytical applications. Tilorone dihydrochloride is an orally active interferon (IFN) inducer with broad-spectrum antiviral activities. Tilorone dihydrochloride possesses robust anti-Severe fever with thrombocytopenia syndrome virus (SFTSV) activity in vitro and in vivo through stimulation of host innate immunity. Tilorone dihydrochloride can penetrate the blood-brain barrier to activate HIF in the CNS[1][2][3].Tilorone dihydrochloride exhibits an inhibitory activity with EC50 of 230 nM against Ebola virus (EBOV)[4].

Formula: N/A

References: [1]Jingjing Yang, et al. Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus. Virol Sin. 2022 Feb;37(1):145-148./[2]Sean Ekins, et al. Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e00440-20./[3]Rajiv R Ratan, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Ann N Y Acad Sci. 2008 Dec:1147:383-94./[4]Ekins S, et al., Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01711-17.

CAS Number: 27591-69-1

Molecular Weight: N/A

Research Area: Infection; Neurological Disease

Target: HIF/HIF Prolyl-Hydroxylase;Influenza Virus

• Artikelnummer: MEXHY-B1080R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1080R-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK