Tipranavir (Standard), CAS 174484-41-4

Product Description: Tipranavir (Standard) is the analytical standard of Tipranavir. This product is intended for research and analytical applications. Tipranavir (PNU-140690) inhibits the enzymatic activity and dimerization of HIV-1 protease, exerts potent activity against multi-protease inhibitor (PI)-resistant HIV-1 isolates with IC50s of 66-410 nM[1][2]. Tipranavir inhibits SARS-CoV-2 3CLpro activity[3].

Formula: N/A

References: [1]Aoki M, et al. Loss of the protease dimerization inhibition activity of tipranavir (TPV) and its association with the acquisition of resistance to TPV by HIV-1. J Virol. 2012 Dec;86(24):13384-96./[2]Li F, et al. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May;38(5):871-8./[3]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.

CAS Number: 174484-41-4

Molecular Weight: N/A

Research Area: Infection

Target: HIV;HIV Protease;SARS-CoV

• Artikelnummer: MEXHY-15148R-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15148R-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK