Toremifene, CAS 89778-26-7

Product Description: Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

Applications: Cancer-programmed cell death

Formula: C26H28ClNO

Citations: bioRxiv. 2020 May./J Pharmaceut Biomed. 2020, 113870./Patent. US11696914./Research Square Preprint. 2020 Nov 4;rs.3.rs-100914./J Med Chem. 2020 Oct 8;63(19):11085-11099./Viruses. 2021 Jun 28;13(7):1255.

References: [1]Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35./[2]Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene - Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108(1-2): 1-7./[3]Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31(5):523-9./[4]Laura Cooper, et al. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. J Med Chem. 2020 Sep 4.

CAS Number: 89778-26-7

Molecular Weight: 405.96

Compound Purity: 99.86

Research Area: Cancer; Infection

Solubility: DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Estrogen Receptor/ERR

• Artikelnummer: MEXHY-B0005A-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0005A-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK