Transthyretin-IN-3, CAS 3008535-20-1

Product Description: Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin (TTR) to inhibit Amyloid aggregation (IC50=5.0±0.2 μM). Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers[1].

Applications: Neuroscience-Neuromodulation

Formula: C17H11ClI2O3

References: [1]Mizuguchi, Mineyuki, et al. "Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma." Journal of Medicinal Chemistry (2024).

CAS Number: 3008535-20-1

Molecular Weight: 552.53

Research Area: Others

Solubility: 10 mM in DMSO

Target: Transthyretin (TTR)

• Artikelnummer: MEXHY-161505-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161505-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK