Triclosan (Standard), CAS 3380-34-5

Product Description: Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models[1][2][3].

Formula: N/A

References: [1]R J Heath, et al. Mechanism of triclosan inhibition of bacterial fatty acid synthesis. J Biol Chem. 1999 Apr 16;274(16):11110-4./[2]Bo Kyung Park, et al. Effects of Triclosan on Neural Stem Cell Viability and Survival. Biomol Ther (Seoul). 2016 Jan;24(1):99-107./[3]Jianan Zhang, et al. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun. 2022 Jan 10;13(1):136.

CAS Number: 3380-34-5

Molecular Weight: N/A

Research Area: Infection; Cancer

Target: Antibiotic;Apoptosis;Bacterial;Fungal

• Artikelnummer: MEXHY-B1119R-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1119R-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK