UCL 1684 (dibromide), CAS 199934-16-2

Product Description: UCL 1684 (dibromide) is a first nanomolar, non-peptidic small conductance calcium-activated potassium (SK) channel blocker. UCL 1684 (dibromide) is effective in preventing the development of atrial fibrillation due to potent atrial-selective inhibition of INa. UCL 1684 (dibromide) causes atrial-selective prolongation of ERP secondary to induction of postrepolarization refractoriness[1][2][3].

Applications: Neuroscience-Neuromodulation

Formula: C34H30Br2N4

References: [1]Burashnikov A, et al. The Small Conductance Calcium-Activated Potassium Channel Inhibitors NS8593 and UCL1684 Prevent the Development of Atrial Fibrillation Through Atrial-Selective Inhibition of Sodium Channel Activity. J Cardiovasc Pharmacol. 2020;76(2):164-172./[2]Rosa JC, et al. Bis-quinolinium cyclophanes: 6,10-diaza-3(1,3),8(1,4)-dibenzena-1,5(1,4)- diquinolinacyclodecaphane (UCL 1684), the first nanomolar, non-peptidic blocker of the apamin-sensitive Ca(2+)-activated K+ channel. J Med Chem. 1998;41(1):2-5./[3]Diness JG, et al. Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition. Hypertension. 2011;57(6):1129-1135.

CAS Number: 199934-16-2

Molecular Weight: 654.44

Compound Purity: 98.0

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Potassium Channel

• Artikelnummer: MEXHY-108579-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-108579-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK