USP28-IN-4, CAS 2931509-15-6

Product Description: USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1].

Applications: Cancer-programmed cell death

Formula: C22H18Cl2N2O3S

References: [1]Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254:115369.

CAS Number: 2931509-15-6

Molecular Weight: 461.36

Compound Purity: 99.35

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic;adjust pH to 6 with HCl)

Target: Deubiquitinase

• Artikelnummer: MEXHY-149230-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-149230-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK