Verrucarin A, CAS 3148-09-2

Product Description: Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53[1][2].

Applications: Cancer-Kinase/protease

Formula: C27H34O9

References: [1]Palanivel K, et al. Verrucarin A alters cell-cycle regulatory proteins and induces apoptosis through reactive oxygen species-dependent p38MAPK activation in the human breast cancer cell line MCF-7. Tumour Biol. 2014;35(10):10159-10167./[2]Palanivel K, et al. Verrucarin A, a protein synthesis inhibitor, induces growth inhibition and apoptosis in breast cancer cell lines MDA-MB-231 and T47D. Biotechnol Lett. 2013;35(9):1395-1403.

CAS Number: 3148-09-2

Molecular Weight: 502.55

Compound Purity: 99.89

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Reactive Oxygen Species

• Artikelnummer: MEXHY-107426-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-107426-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK