VHL-IN-1, CAS 3033117-53-9

Product Description: VHL-IN-1 (compound 30) is a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor (dissociation constant Kd=37 nM) that stabilizes and induces HIF-1α transcriptional activity. VHL-IN-1 has potential as a HIF-1α stabilizer and degrader of proteolytically targeted chimeras (PROTACs)[1].

Applications: Cancer-programmed cell death

Formula: C28H37FN4O4S

References: [1]Vu LP, et al. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers. J Med Chem. 2023 Sep 14.. .

CAS Number: 3033117-53-9

Molecular Weight: 544.68

Compound Purity: 99.78

Research Area: cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: HIF/HIF Prolyl-Hydroxylase;Ligands for E3 Ligase;PROTACs

• Artikelnummer: MEXHY-156106-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-156106-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK