VU 0240551, CAS 893990-34-6

Product Description: VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].

Formula: C16H14N4OS2

References: [1]Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8./[2]Wang Y, et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409./[3]Balapattabi K, et al. Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. J Neuroendocrinol. 2019;31(8):e12752.

CAS Number: 893990-34-6

Molecular Weight: 342.44

Compound Purity: 99.97

Research Area: Others

Solubility: DMSO : ≥ 50 mg/mL

Target: Potassium Channel

• Artikelnummer: MEXHY-16689-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16689-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK