XYD198

Product Description: XYD198 (Compound 14h) is an orally active degrader for CBP/p300. XYD198 inhibits CBP/p300 bromodomain with IC50 of 213.5 nM. XYD198 exhibits antitumor activity against acute myeloid leukemia. (Structure: Pink, CBP/p300 ligand 4 (HY-161495); Blue, E3 ligase ligand (HY-14658); Black: linker (HY-161499))[1]

Formula: C54H49F2N11O7

References: [1]Hu J, et al., Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67(9):6952-6986. 

Molecular Weight: 1002.03

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Epigenetic Reader Domain;PROTACs

• Artikelnummer: MEXHY-161498-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-161498-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK