YX-02-030

Product Description: YX-02-030M is a PROTAC MDM2 degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1α binding with IC50s of 63 nM and 1.35 μM respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers (TNBC) cells. (Blue: VHL ligand; Black: linker; Pink: MDM2 inhibitor)[1].

Formula: C66H85Cl2N9O10S

References: [1]Adams CM, et al. Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer. Cancer Discov. 2023 May 4;13(5):1210-1229.

Molecular Weight: 1267.41

Research Area: Cancer

Target: MDM-2/p53;PROTACs

• Artikelnummer: MEXHY-158684-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-158684-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK