ZBP1/RIP3/MLKL activator 1

Product Description: ZBP1/RIP3/MLKL activator 1 (compound 3a) is a synthetically derived quinoline compound. ZBP1/RIP3/MLKL Activator 1 induces DNA damage, enhances intracellular levels of reactive oxygen species (ROS), and triggers apoptosis via the caspase pathway. Furthermore, when apoptosis is inhibited, ZBP1/RIP3/MLKL Activator 1 promotes necroptotic cell death through the ZBP1-RIP3-MLKL pathway. ZBP1/RIP3/MLKL Activator 1 is utilized in oncological research, particularly in the selective targeting of cells with impaired apoptotic function[1].

Formula: C26H28N6O2

References: [1]Saha R, et al. Mono-quinoxaline-induced DNA structural alteration leads to ZBP1/RIP3/MLKL-driven necroptosis in cancer cells[J]. European Journal of Medicinal Chemistry, 2024, 270: 116377.

Molecular Weight: 456.54

Research Area: Cancer

Target: Mixed Lineage Kinase;Necroptosis;RIP kinase

• Artikelnummer: MEXHY-162424-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-162424-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK