(Z)-Capsaicin, CAS 25775-90-0

Formulation: A solid

Formal Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Purity: ≥95%

Formula Markup: C18H27NO3

Formula Weight: 305,4

Shelf life (days): 1460

CAS Number: 25775-90-0

Notes: (Z)-Capsaicin is an alkaloid that has been found in Capsicum, has diverse biological activities, and is the cis-isomer of capsaicin (Item Nos. 92350 / 10010743).{66641,66642,66643,7203,66644,66645} It is an agonist of transient receptor potential vanilloid 1 (TRPV1), inducing calcium uptake in CHO cells expressing human TRPV1 (EC50 = 28.2 nM).{66642} (Z)-Capsaicin (10 µM) shortens the action potential duration in isolated canine Purkinje fibers.{66643} It increases the latency to paw withdrawal in the hot plate test in rats when administered at a dose of 0.68 mmol/animal.{7203} Topical application of (Z)-capsaicin (25 µl of a 1% solution) reduces croton oil-induced ear edema in mice. It induces emesis in musk shrews (S. murinus).{66644} (Z)-Capsaicin decreases disease severity in a guinea pig model of genital herpes induced by herpes simplex virus 2 (HSV-2).{66645} Formulations containing (Z)-capsaicin have been used in the treatment of osteoarthritis and neuropathic pain.

• Artikelnummer: CAY39929-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39929-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK