(±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5

Formulation: A solution in ethanol

Formal Name: 10-hydroxyoctadec-12Z-enoic-17,17,18,18,18-d5 acid

Purity: ≥95%

Formula Markup: C18H29D5O3

Formula Weight: 303,5

Shelf life (days): 365

Notes: (±)-10-hydroxy-12(Z)-Octadecenoic acid-d5 is intended for use as an internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid (Item No. 37281) by GC- or LC-MS. (±)-10-hydroxy-12(Z)-Octadecenoic acid is an oxylipin and a metabolite of linoleic acid (Item Nos. 90150 / 90150.1 / 21909).{62769} It is formed from linoleic acid by conjugated linoleic acid-hydrase (CLA-HY) as an intermediate in CLA biosynthesis and can also be produced from linoleic acid by gut microbiota. (±)-10-hydroxy-12(Z)-Octadecenoic acid (30 µM) inhibits LPS-induced nitric oxide (NO) production, ERK phosphorylation, and increases in inducible NO synthase (iNOS) levels in BV-2 microglia cells.{66125} It reduces TNF-α, NO2, and IL-10 levels in LPS-stimulated and -unstimulated isolated dendritic bone marrow cells when used at a concentration of 100 µM.{66124} (±)-10-hydroxy-12(Z)-Octadecenoic acid (100 µM) decreases LPS-induced maturation of dendritic cells in isolated mouse bone marrow cells.

• Artikelnummer: CAY37282-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37282-25
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung