AA147, CAS 393121-74-9

Formulation: A solid

Formal Name: N-(2-hydroxy-5-methylphenyl)-benzenepropanamide

Purity: ≥95%

Formula Markup: C16H17NO2

Formula Weight: 255,3

Shelf life (days): 1460

CAS Number: 393121-74-9

Notes: AA147 is an endoplasmic reticulum (ER) proteostasis regulator.{66093,69355,69356} It activates an activating transcription factor 6-dependent (ATF6-dependent) ER stress response element reporter and antioxidant response element reporter in HT22 hippocampal cells (EC50s = 3.6 and 3.92 µM, respectively) and protects against glutamate-induced cytotoxicity and prevents increases in reactive oxygen species (ROS) in HT22 cells when used at a concentration of 10 µM.{66093} AA147 (10 µM) reduces cell death induced by the unfolded protein response (UPR) activator tunicamycin and increases ER-associated protein degradation (ERAD) in neonatal rat ventricular myocytes.{69355} It reduces the myocardial, renal, and cerebral infarct size as a percentage of the area at risk in mouse models of ischemia-reperfusion injury induced by left anterior descending coronary artery (LAD) ligation, renal portal system occlusion, or middle cerebral artery occlusion (MCAO), respectively, when administered at a dose of 2 mg/kg. AA147 also prevents the production of non-structural protein 5 (NS5) in dengue virus-infected Huh7 cells (IC50 = ~1 µM).{69356}

• Artikelnummer: CAY27143-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27143-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe