Formulation: A solid
Formal Name: N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furan-2,3,3,4,4,5,5-d7-carboxamide
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C19H20D7N5O4
Formula Weight: 396,5
Shelf life (days): 1460
CAS Number: 1133386-93-2
Notes: Alfuzosin-d7 is intended for use as an internal standard for the quantification of alfuzosin (Item No. 13648) by GC- or LC-MS. Alfuzosin is an antagonist of α1-adrenergic receptors (α1-ARs; Kis = 10, 10, and 3.16 nM for α1A-, α1B-, and α1D-ARs, respectively).{18268} It increases the amount of phenylephrine needed to increase urethral and arterial blood pressure in pithed rats when administered at a dose of 10 mg/kg.{67081} Formulations containing alfuzosin have been used in the treatment of benign prostatic hyperplasia.