Formulation: A solid
Formal Name: L-lysyl-L-lysyl-L-methionyl-L-methionyl-L-lysyl-L-lysylglycylglycyl-L-lysyl-L-phenylalanylglycyl-L-threonyl-L-phenylalanyl-L-methionyl-L-arginine, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C98H168N28O22S3 • XCF3COOH
Formula Weight: 2186,8
Shelf life (days): 1460
Notes: AMPR-22 is a synthetic antimicrobial peptide derived from the mitochondrial cation channel reactive oxygen species (ROS) modulator 1 (Romo1).{66141} It is active against S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and carbapenem-resistant P. aeruginosa with minimum bactericidal concentration (MBC) values of 2, 2, 2, and 4 µg/ml, respectively. AMPR-22 induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa in a concentration-dependent manner. It increases survival in a mouse model of sepsis induced by S. aureus when administered at a dose of 10 mg/kg.