ASTX660, CAS 1799328-86-1

Formulation: A solid

Formal Name: 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-ethanone

Purity: ≥98%

Formula Markup: C30H42FN5O3

Formula Weight: 539,7

Shelf life (days): 1460

CAS Number: 1799328-86-1

Notes: ASTX660 is an inhibitor of inhibitor of apoptosis (IAP) protein-peptide interactions.{64604} It inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s = 50 = 2.8 nM) and induces displacement of Smac from XIAP in A375 melanoma cells. It induces apoptosis in MDA-MB-231, A375, and SK-MEL-28 cells in a TNF-α-dependent manner. In vivo, ASTX660 (20 mg/kg) reduces tumor growth in MDA-MB-231 breast cancer and A375 melanoma mouse xenograft models.

• Artikelnummer: CAY36619-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36619-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe