BCP-T.A., CAS 2786829-70-5

Formulation: A solid

Formal Name: [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)-methanone

Purity: ≥98%

Shelf life (days): 730

CAS Number: 2786829-70-5

Notes: BCP-T.A. is a ferroptosis inducer.{65463} It induces ferroptosis in NCI H522 non-small cell lung cancer (NSCLC) cells (IC50 = 17 nM), an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 (Item No. 17730). BCP-T.A. binds to glutathione peroxidase (GPX4) and increases the accumulation of lipid peroxides in NCI H522 cells when used at a concentration of 0.5 µM. It is cytotoxic to WI38 human lung fibroblasts and mouse embryonic fibroblasts (MEFs; IC50s = 22 and 10 nM, respectively), as well as NCI H522, HT-1080 fibrosarcoma, MDA-MB-468 and MDA-MB-231 breast, and HeLa cervical cancer cells (IC50s = 17, 19, 84, 21, and 242 nM, respectively).

• Artikelnummer: CAY37659-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37659-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe