Carmustine-d8

Formulation: A solid

Formal Name: N,N'-bis(2-chloroethyl-d8)-N-nitroso-urea

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C5HD8Cl2N3O2

Formula Weight: 222,1

Shelf life (days): 1460

Notes: Carmustine-d8 is intended for use as an internal standard for the quantification of carmustine (Item No. 15775) by GC- or LC-MS. Carmustine is a DNA alkylating agent.{30628,65461} It inhibits cell growth and induces cell cycle arrest at the G2/M phase in C6 rat glioma cells when used at a concentration of 10 µM.{65461} In vivo, carmustine (0.3 and 6.7 mg/kg per day) reduces tumor growth in a C6 rat glioma model. Carmustine (0.5 mg/kg, i.p.) also reduces the number of amyloid-β plaques and brain levels of amyloid-β (1-40) (Aβ40), as well as increases brain levels of soluble amyloid precursor protein (sAPP) in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{65462} Formulations containing carmustine have been used in the treatment of gliomas and glioblastomas.

• Artikelnummer: CAY42213-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 42213-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung