CB-096, CAS 108883-90-5

Formulation: A solid

Formal Name: 2-methoxy-4-(6-nitro-1H-benzimidazol-2-yl)-phenol

Purity: ≥98%

Formula Markup: C14H11N3O4

Formula Weight: 285,3

Shelf life (days): 1460

CAS Number: 108883-90-5

Notes: CB-096 is an inhibitor of repeat-associated non-ATG (RAN) translation.{69080} It selectively binds to the hexanucleotide GGGGCC repeat expansion (r(G4C2)exp) hairpin r(G4C2)8 (EC50 = 19 µM) over the anti-sense hairpin r(G2C4)8 and base-paired construct r(GGCC)10. CB-096 (25 µM) inhibits RAN translation and the formation of nuclear stress granules in HEK293T cells expressing r(G4C2)66 in an in vitro model of C9orf72 amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (c9ALS/FTD). It also induces relaxation of rat thoracic aortic rings pre-contracted with norepinephrine (EC50 = 1.81 µM) and decreases systolic arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 100 mg/kg.{69081}

• Artikelnummer: CAY36407-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36407-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe